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Methodology and software to detect viral integration site hot-spots
BACKGROUND: Modern gene therapy methods have limited control over where a therapeutic viral vector inserts into the host genome. Vector integration can activate local gene expression, which can cause cancer if the vector inserts near an oncogene. Viral integration hot-spots or 'common insertion...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203353/ https://www.ncbi.nlm.nih.gov/pubmed/21914224 http://dx.doi.org/10.1186/1471-2105-12-367 |