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Efficient internal exon recognition depends on near equal contributions from the 3′ and 5′ splice sites

Pre-mRNA splicing is carried out by the spliceosome, which identifies exons and removes intervening introns. In vertebrates, most splice sites are initially recognized by the spliceosome across the exon, because most exons are small and surrounded by large introns. This gene architecture predicts th...

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Detalles Bibliográficos
Autores principales: Shepard, Peter J., Choi, Eun-A., Busch, Anke, Hertel, Klemens J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203598/
https://www.ncbi.nlm.nih.gov/pubmed/21795381
http://dx.doi.org/10.1093/nar/gkr481