Cargando…
Efficient internal exon recognition depends on near equal contributions from the 3′ and 5′ splice sites
Pre-mRNA splicing is carried out by the spliceosome, which identifies exons and removes intervening introns. In vertebrates, most splice sites are initially recognized by the spliceosome across the exon, because most exons are small and surrounded by large introns. This gene architecture predicts th...
Autores principales: | Shepard, Peter J., Choi, Eun-A., Busch, Anke, Hertel, Klemens J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203598/ https://www.ncbi.nlm.nih.gov/pubmed/21795381 http://dx.doi.org/10.1093/nar/gkr481 |
Ejemplares similares
-
HEXEvent: a database of Human EXon splicing Events
por: Busch, Anke, et al.
Publicado: (2013) -
The splicing regulators Tra and Tra2 are unusually potent activators of pre-mRNA splicing
por: Sciabica, Kathryn S., et al.
Publicado: (2006) -
AG-dependent 3′-splice sites are predisposed to aberrant splicing due to a mutation at the first nucleotide of an exon
por: Fu, Yuan, et al.
Publicado: (2011) -
Global control of aberrant splice-site activation by auxiliary splicing sequences: evidence for a gradient in exon and intron definition
por: Královičová, Jana, et al.
Publicado: (2007) -
Functional properties and evolutionary splicing constraints on a composite exonic regulatory element of splicing in CFTR exon 12
por: Haque, Ariful, et al.
Publicado: (2010)