An activated triple bond linker enables ‘click’ attachment of peptides to oligonucleotides on solid support

A general procedure, based on a new activated alkyne linker, for the preparation of peptide–oligonucleotide conjugates (POCs) on solid support has been developed. With this linker, conjugation is effective at room temperature (RT) in millimolar concentration and submicromolar amounts. This is made p...

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Detalles Bibliográficos
Autores principales: Wenska, Malgorzata, Alvira, Margarita, Steunenberg, Peter, Stenberg, Åsa, Murtola, Merita, Strömberg, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203603/
https://www.ncbi.nlm.nih.gov/pubmed/21795380
http://dx.doi.org/10.1093/nar/gkr603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203603/
https://www.ncbi.nlm.nih.gov/pubmed/21795380
http://dx.doi.org/10.1093/nar/gkr603

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