Cargando…
An activated triple bond linker enables ‘click’ attachment of peptides to oligonucleotides on solid support
A general procedure, based on a new activated alkyne linker, for the preparation of peptide–oligonucleotide conjugates (POCs) on solid support has been developed. With this linker, conjugation is effective at room temperature (RT) in millimolar concentration and submicromolar amounts. This is made p...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203603/ https://www.ncbi.nlm.nih.gov/pubmed/21795380 http://dx.doi.org/10.1093/nar/gkr603 |