Resistance of bulky DNA lesions to nucleotide excision repair can result from extensive aromatic lesion–base stacking interactions

The molecular basis of resistance to nucleotide excision repair (NER) of certain bulky DNA lesions is poorly understood. To address this issue, we have studied NER in human HeLa cell extracts of two topologically distinct lesions, one derived from benzo[a]pyrene (10R-(+)-cis-anti-B[a]P-N(2)-dG), and...

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Detalles Bibliográficos
Autores principales: Reeves, Dara A., Mu, Hong, Kropachev, Konstantin, Cai, Yuqin, Ding, Shuang, Kolbanovskiy, Alexander, Kolbanovskiy, Marina, Chen, Ying, Krzeminski, Jacek, Amin, Shantu, Patel, Dinshaw J., Broyde, Suse, Geacintov, Nicholas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203604/
https://www.ncbi.nlm.nih.gov/pubmed/21764772
http://dx.doi.org/10.1093/nar/gkr537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203604/
https://www.ncbi.nlm.nih.gov/pubmed/21764772
http://dx.doi.org/10.1093/nar/gkr537

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