Crystal Structure of Thrombin in Complex with S-Variegin: Insights of a Novel Mechanism of Inhibition and Design of Tunable Thrombin Inhibitors

The inhibition of thrombin is one of the important treatments of pathological blood clot formation. Variegin, isolated from the tropical bont tick, is a novel molecule exhibiting a unique ‘two-modes’ inhibitory property on thrombin active site (competitive before cleavage, noncompetitive after cleav...

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Detalles Bibliográficos
Autores principales: Koh, Cho Yeow, Kumar, Sundramurthy, Kazimirova, Maria, Nuttall, Patricia A., Radhakrishnan, Uvaraj P., Kim, Seongcheol, Jagadeeswaran, Pudur, Imamura, Takayuki, Mizuguchi, Jun, Iwanaga, Sadaaki, Swaminathan, Kunchithapadam, Kini, R. Manjunatha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203879/
https://www.ncbi.nlm.nih.gov/pubmed/22053189
http://dx.doi.org/10.1371/journal.pone.0026367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203879/
https://www.ncbi.nlm.nih.gov/pubmed/22053189
http://dx.doi.org/10.1371/journal.pone.0026367

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