Cargando…

Crystal Structure of Thrombin in Complex with S-Variegin: Insights of a Novel Mechanism of Inhibition and Design of Tunable Thrombin Inhibitors

The inhibition of thrombin is one of the important treatments of pathological blood clot formation. Variegin, isolated from the tropical bont tick, is a novel molecule exhibiting a unique ‘two-modes’ inhibitory property on thrombin active site (competitive before cleavage, noncompetitive after cleav...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koh, Cho Yeow, Kumar, Sundramurthy, Kazimirova, Maria, Nuttall, Patricia A., Radhakrishnan, Uvaraj P., Kim, Seongcheol, Jagadeeswaran, Pudur, Imamura, Takayuki, Mizuguchi, Jun, Iwanaga, Sadaaki, Swaminathan, Kunchithapadam, Kini, R. Manjunatha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203879/ https://www.ncbi.nlm.nih.gov/pubmed/22053189 http://dx.doi.org/10.1371/journal.pone.0026367

Ejemplares similares

Zebrafish Thrombocytes: Functions and Origins
por: Khandekar, Gauri, et al.
Publicado: (2012)

Modifying the Substrate Specificity of Carcinoscorpius rotundicauda Serine Protease Inhibitor Domain 1 to Target Thrombin
por: Giri, Pankaj Kumar, et al.
Publicado: (2010)

Evolution of Primary Hemostasis in Early Vertebrates
por: Kim, Seongcheol, et al.
Publicado: (2009)

PURIFICATION OF THROMBIN
por: Milstone, H.
Publicado: (1942)

G6f-Like Is an ITAM-Containing Collagen Receptor in Thrombocytes
por: Hughes, Craig E., et al.
Publicado: (2012)

Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
por: Koh, Cho Yeow, et al.
Publicado: (2021)

Dabigatran Monitoring Was Influenced by Thrombin Time Reagent With Different Thrombin Concentrations
por: Xu, Xiaoping, et al.
Publicado: (2019)

A method to measure thrombin activity in a mixture of fibrinogen and thrombin powders
por: DeAnglis, Ashley P., et al.
Publicado: (2017)

Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay
por: Carlo, Audrey, et al.
Publicado: (2022)

Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization
Publicado: (1993)

Comparative Analysis of Thrombin Calibration Algorithms and Correction for Thrombin-α2macroglobulin Activity
por: Chang, William C., et al.
Publicado: (2020)

Aprotinin Inhibits Thrombin Generation by Inhibition of the Intrinsic Pathway, but is not a Direct Thrombin Inhibitor
por: Lisman, Ton, et al.
Publicado: (2021)

Ximelagatran: Direct Thrombin Inhibitor
por: Ho, Shir-Jing, et al.
Publicado: (2006)

Chemotactic response of monocytes to thrombin
Publicado: (1983)

Inhibition of Intrinsic Thrombin Generation
por: Stief, Thomas W.
Publicado: (2006)

Thrombin Generation in Zebrafish Blood
por: Schurgers, Evelien, et al.
Publicado: (2016)

Editorial: Advances in thrombin generation
por: de Laat-Kremers, Romy, et al.
Publicado: (2023)

Thrombin Generation in Chinese Pregnant Women and the Effect of Insulin Use on Thrombin Generation in Patients with GDM
por: Dong, Feng, et al.
Publicado: (2019)

Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis
por: Kremers, Romy M. W., et al.
Publicado: (2017)

Cell-Free DNA Promotes Thrombin Autolysis and Generation of Thrombin-Derived C-Terminal Fragments
por: Saravanan, Rathi, et al.
Publicado: (2021)

Monoclonal antibody to the thrombin receptor stimulates DNA synthesis in combination with gamma-thrombin or phorbol myristate acetate
Publicado: (1987)

Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity
por: Dolot, Rafal, et al.
Publicado: (2018)

Purification and characterization of thrombin from camel plasma: interaction with camel tick salivary gland thrombin inhibitor
por: Ibrahim, Mahmoud A., et al.
Publicado: (2023)

The unresolved safety concerns of bovine thrombin
por: Shander, Aryeh, et al.
Publicado: (2008)

OBSERVATIONS ON THROMBIN INACTIVATION BY HUMAN SERUM
por: Mihályi, Elemer
Publicado: (1953)

STUDIES ON THROMBIN-INDUCED PLATELET AGGLUTINATION
por: Shermer, Richard W., et al.
Publicado: (1961)

Thrombin Inhibitors from Different Animals
por: Tanaka-Azevedo, A. M., et al.
Publicado: (2010)

Safety of topical thrombins: the ongoing debate
por: Lomax, Christopher
Publicado: (2009)

Platelet thrombin receptor antagonism and atherothrombosis
por: Angiolillo, Dominick J., et al.
Publicado: (2010)

The Extended Cleavage Specificity of Human Thrombin
por: Gallwitz, Maike, et al.
Publicado: (2012)

Anticoagulants and the Propagation Phase of Thrombin Generation
por: Orfeo, Thomas, et al.
Publicado: (2011)

Thrombin Receptor Antagonism in Antiplatelet Therapy
por: Olivier, C., et al.
Publicado: (2013)

The Characteristics of Thrombin in Osteoarthritic Pathogenesis and Treatment
por: Chou, Pei-Yu, et al.
Publicado: (2014)

Correlated Motions and Residual Frustration in Thrombin
por: Fuglestad, Brian, et al.
Publicado: (2013)

The Importance of Thrombin in Cerebral Injury and Disease
por: Krenzlin, Harald, et al.
Publicado: (2016)

Thrombin Generation in Acute Ischaemic Stroke
por: Balogun, Ibrahim O., et al.
Publicado: (2016)

Reversible covalent direct thrombin inhibitors
por: Sivaraja, Mohanram, et al.
Publicado: (2018)

Thrombin generation in low plasma volumes
por: Bloemen, Saartje, et al.
Publicado: (2018)

The role of thrombin in the pathogenesis of diabetic neuropathy
por: Shavit-Stein, Efrat, et al.
Publicado: (2019)

Thrombin Generation and Cancer: Contributors and Consequences
por: Reddel, Caroline J., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ttfm9u3v4s8rsd1pc1sgut9gma