Halofuginone Has Anti-Proliferative Effects in Acute Promyelocytic Leukemia by Modulating the Transforming Growth Factor Beta Signaling Pathway

Promyelocytic leukemia-retinoic acid receptor alpha (PML-RARα) expression in acute promyelocytic leukemia (APL) impairs transforming growth factor beta (TGFβ) signaling, leading to cell growth advantage. Halofuginone (HF), a low-molecular-weight alkaloid that modulates TGFβ signaling, was used to tr...

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Detalles Bibliográficos
Autores principales: de Figueiredo-Pontes, Lorena L., Assis, Patricia A., Santana-Lemos, Bárbara A. A., Jácomo, Rafael H., Lima, Ana Sílvia G., Garcia, Aglair B., Thomé, Carolina H., Araújo, Amélia G., Panepucci, Rodrigo A., Zago, Marco A., Nagler, Arnon, Falcão, Roberto P., Rego, Eduardo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203897/
https://www.ncbi.nlm.nih.gov/pubmed/22053203
http://dx.doi.org/10.1371/journal.pone.0026713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203897/
https://www.ncbi.nlm.nih.gov/pubmed/22053203
http://dx.doi.org/10.1371/journal.pone.0026713

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