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The FSHD Atrophic Myotube Phenotype Is Caused by DUX4 Expression

BACKGROUND: Facioscapulohumeral muscular dystrophy (FSHD) is linked to deletions in 4q35 within the D4Z4 repeat array in which we identified the double homeobox 4 (DUX4) gene. We found stable DUX4 mRNAs only derived from the most distal D4Z4 unit and unexpectedly extended to the flanking pLAM region...

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Detalles Bibliográficos
Autores principales:	Vanderplanck, Céline, Ansseau, Eugénie, Charron, Sébastien, Stricwant, Nadia, Tassin, Alexandra, Laoudj-Chenivesse, Dalila, Wilton, Steve D., Coppée, Frédérique, Belayew, Alexandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203905/ https://www.ncbi.nlm.nih.gov/pubmed/22053214 http://dx.doi.org/10.1371/journal.pone.0026820

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