A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells

BACKGROUND: Cells of most human cancers have supernumerary centrosomes. To enable an accurate chromosome segregation and cell division, these cells developed a yet unresolved molecular mechanism, clustering their extra centrosomes at two poles, thereby mimicking mitosis in normal cells. Failure of t...

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Detalles Bibliográficos
Autores principales: Castiel, Asher, Visochek, Leonid, Mittelman, Leonid, Dantzer, Françoise, Izraeli, Shai, Cohen-Armon, Malka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204305/
https://www.ncbi.nlm.nih.gov/pubmed/21943092
http://dx.doi.org/10.1186/1471-2407-11-412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204305/
https://www.ncbi.nlm.nih.gov/pubmed/21943092
http://dx.doi.org/10.1186/1471-2407-11-412

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