Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition

Despite the initial effectiveness of the tyrosine kinase inhibitor lapatinib against HER2 gene-amplified breast cancers, most patients eventually relapse after treatment, implying that tumors acquire mechanisms of drug resistance. To discover these mechanisms, we generated six lapatinib-resistant HE...

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Detalles Bibliográficos
Autores principales: Rexer, Brent N., Ham, Amy-Joan L., Rinehart, Cammie, Hill, Salisha, Granja-Ingram, Nara de Matos, González, Ana María, Mills, Gordon B., Dave, Bhuvanesh, Chang, Jenny C., Liebler, Daniel C., Arteaga, Carlos L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204390/
https://www.ncbi.nlm.nih.gov/pubmed/21499296
http://dx.doi.org/10.1038/onc.2011.130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204390/
https://www.ncbi.nlm.nih.gov/pubmed/21499296
http://dx.doi.org/10.1038/onc.2011.130

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