A Point Mutation in Translation Initiation Factor eIF2B Leads to Function- and Time-Specific Changes in Brain Gene Expression

BACKGROUND: Mutations in eukaryotic translation initiation factor 2B (eIF2B) cause Childhood Ataxia with CNS Hypomyelination (CACH), also known as Vanishing White Matter disease (VWM), which is associated with a clinical pathology of brain myelin loss upon physiological stress. eIF2B is the guanine...

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Detalles Bibliográficos
Autores principales: Marom, Liraz, Ulitsky, Igor, Cabilly, Yuval, Shamir, Ron, Elroy-Stein, Orna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205039/
https://www.ncbi.nlm.nih.gov/pubmed/22073122
http://dx.doi.org/10.1371/journal.pone.0026992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205039/
https://www.ncbi.nlm.nih.gov/pubmed/22073122
http://dx.doi.org/10.1371/journal.pone.0026992

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