Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization

Positive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChRs) have attracted considerable interest as a novel area of therapeutic drug discovery. Two types of α7-selective PAMs have been identified (type I and type II). Whilst both potentiate peak agonist-induced responses, the...

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Detalles Bibliográficos
Autores principales: Collins, Toby, Young, Gareth T., Millar, Neil S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205184/
https://www.ncbi.nlm.nih.gov/pubmed/21820451
http://dx.doi.org/10.1016/j.neuropharm.2011.07.035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205184/
https://www.ncbi.nlm.nih.gov/pubmed/21820451
http://dx.doi.org/10.1016/j.neuropharm.2011.07.035

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