Saccharomyces cerevisiae THI4p is a suicidal thiamin thiazole synthase

Thiamin pyrophosphate 1 (Figure 1A) is an essential cofactor in all living systems(1). Its biosynthesis involves the separate syntheses of the pyrimidine 2 and thiazole 3 precursors, which are then coupled(2). Two biosynthetic routes to the thiamin thiazole have been identified. In prokaryotes, five...

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Detalles Bibliográficos
Autores principales: Chatterjee, Abhishek, Abeydeera, N. Dinuka, Bale, Shridhar, Pai, Pei-Jing, Dorrestein, Pieter C., Russell, David H., Ealick, Steven E., Begley, Tadhg P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205460/
https://www.ncbi.nlm.nih.gov/pubmed/22031445
http://dx.doi.org/10.1038/nature10503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205460/
https://www.ncbi.nlm.nih.gov/pubmed/22031445
http://dx.doi.org/10.1038/nature10503

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