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Direct observation of disulfide isomerization in a single protein

Photochemical uncaging techniques use light to release active molecules from otherwise inert compounds. Here we expand this class of techniques by demonstrating the mechanical uncaging of a reactive species within a single protein. We prove this novel technique by capturing the regiospecific reactio...

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Detalles Bibliográficos
Autores principales: Alegre-Cebollada, Jorge, Kosuri, Pallav, Rivas-Pardo, Jaime Andrés, Fernández, Julio M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205468/
https://www.ncbi.nlm.nih.gov/pubmed/22024885
http://dx.doi.org/10.1038/nchem.1155