Cargando…
An Inducible Cell-Cell Fusion System with Integrated Ability to Measure the Efficiency and Specificity of HIV-1 Entry Inhibitors
HIV-1 envelope glycoproteins (Envs) mediate virus entry by fusing the viral and target cell membranes, a multi-step process that represents an attractive target for inhibition. Entry inhibitors with broad-range activity against diverse isolates of HIV-1 may be extremely useful as lead compounds for...
Autores principales: | Herschhorn, Alon, Finzi, Andres, Jones, David M., Courter, Joel R., Sugawara, Akihiro, Smith, Amos B., Sodroski, Joseph G. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206054/ https://www.ncbi.nlm.nih.gov/pubmed/22069466 http://dx.doi.org/10.1371/journal.pone.0026731 |
Ejemplares similares
-
A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry
por: Herschhorn, Alon, et al.
Publicado: (2014) -
An entry-competent intermediate state of the HIV-1 envelope glycoproteins
por: Herschhorn, Alon, et al.
Publicado: (2017) -
Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins
por: Herschhorn, Alon, et al.
Publicado: (2016) -
Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV-1 Entry: Conversion of a Viral Entry Agonist to an Antagonist
por: Courter, Joel R., et al.
Publicado: (2014) -
Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer
por: Mao, Youdong, et al.
Publicado: (2013)