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The Temporal Order of Genetic and Pathway Alterations in Tumorigenesis
Cancer evolves through the accumulation of mutations, but the order in which mutations occur is poorly understood. Inference of a temporal ordering on the level of genes is challenging because clinically and histologically identical tumors often have few mutated genes in common. This heterogeneity m...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206070/ https://www.ncbi.nlm.nih.gov/pubmed/22069497 http://dx.doi.org/10.1371/journal.pone.0027136 |