Structural, Stability, Dynamic and Binding Properties of the ALS-Causing T46I Mutant of the hVAPB MSP Domain as Revealed by NMR and MD Simulations

T46I is the second mutation on the hVAPB MSP domain which was recently identified from non-Brazilian kindred to cause a familial amyotrophic lateral sclerosis (ALS). Here using CD, NMR and molecular dynamics (MD) simulations, we characterized the structure, stability, dynamics and binding capacity o...

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Detalles Bibliográficos
Autores principales: Lua, Shixiong, Qin, Haina, Lim, Liangzhong, Shi, Jiahai, Gupta, Garvita, Song, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206076/
https://www.ncbi.nlm.nih.gov/pubmed/22069488
http://dx.doi.org/10.1371/journal.pone.0027072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206076/
https://www.ncbi.nlm.nih.gov/pubmed/22069488
http://dx.doi.org/10.1371/journal.pone.0027072

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