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Single-channel Ca(2+) imaging implicates Aβ1–42 amyloid pores in Alzheimer’s disease pathology

Oligomeric forms of Aβ peptides are implicated in Alzheimer’s disease (AD) and disrupt membrane integrity, leading to cytosolic calcium (Ca(2+)) elevation. Proposed mechanisms by which Aβ mediates its effects include lipid destabilization, activation of native membrane channels, and aggregation of A...

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Detalles Bibliográficos
Autores principales:	Demuro, Angelo, Smith, Martin, Parker, Ian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206345/ https://www.ncbi.nlm.nih.gov/pubmed/22024165 http://dx.doi.org/10.1083/jcb.201104133

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