Single-channel Ca(2+) imaging implicates Aβ1–42 amyloid pores in Alzheimer’s disease pathology

Oligomeric forms of Aβ peptides are implicated in Alzheimer’s disease (AD) and disrupt membrane integrity, leading to cytosolic calcium (Ca(2+)) elevation. Proposed mechanisms by which Aβ mediates its effects include lipid destabilization, activation of native membrane channels, and aggregation of A...

Descripción completa

Detalles Bibliográficos
Autores principales: Demuro, Angelo, Smith, Martin, Parker, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206345/
https://www.ncbi.nlm.nih.gov/pubmed/22024165
http://dx.doi.org/10.1083/jcb.201104133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206345/
https://www.ncbi.nlm.nih.gov/pubmed/22024165
http://dx.doi.org/10.1083/jcb.201104133

Ejemplares similares