Activity and Architecture of Pyroglutamate-Modified Amyloid-β (Aβ(pE3-42)) Pores

[Image: see text] Among the family of Aβ peptides, pyroglutamate-modified Aβ (Aβ(pE)) peptides are particularly associated with cytotoxicity in Alzheimer’s disease (AD). They represent the dominant fraction of Aβ oligomers in the brains of AD patients, but their accumulation in the brains of elderly...

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Detalles Bibliográficos
Autores principales: Gillman, Alan L., Jang, Hyunbum, Lee, Joon, Ramachandran, Srinivasan, Kagan, Bruce L., Nussinov, Ruth, Teran Arce, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096221/
https://www.ncbi.nlm.nih.gov/pubmed/24922585
http://dx.doi.org/10.1021/jp5040954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096221/
https://www.ncbi.nlm.nih.gov/pubmed/24922585
http://dx.doi.org/10.1021/jp5040954

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