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Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer’s Disease Pathology
Amyloid beta (Aβ) oligomers associated with Alzheimer’s disease (AD) form Ca(2+)-permeable plasma membrane pores, leading to a disruption of the otherwise well-controlled intracellular calcium (Ca(2+)) homeostasis. The resultant up-regulation of intracellular Ca(2+) concentration has detrimental imp...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562663/ https://www.ncbi.nlm.nih.gov/pubmed/26348728 http://dx.doi.org/10.1371/journal.pone.0137357 |