Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling

BACKGROUND: Epithelial neoplasias are associated with alterations in cell polarity and excessive cell proliferation, yet how these neoplastic properties are related to one another is still poorly understood. The study of Drosophila genes that function as neoplastic tumor suppressors by regulating bo...

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Detalles Bibliográficos
Autores principales: Doggett, Karen, Grusche, Felix A, Richardson, Helena E, Brumby, Anthony M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206446/
https://www.ncbi.nlm.nih.gov/pubmed/21955824
http://dx.doi.org/10.1186/1471-213X-11-57

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206446/
https://www.ncbi.nlm.nih.gov/pubmed/21955824
http://dx.doi.org/10.1186/1471-213X-11-57

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