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Haloduracin α Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry
[Image: see text] The two-peptide lantibiotic haloduracin is composed of two post-translationally modified polycyclic peptides that synergistically act on Gram-positive bacteria. We show here that Halα inhibits the transglycosylation reaction catalyzed by PBP1b by binding in a 2:1 stoichiometry to i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206492/ https://www.ncbi.nlm.nih.gov/pubmed/22003874 http://dx.doi.org/10.1021/ja206281k |