The Protein Kinase C Agonist PEP005 (Ingenol 3-Angelate) in the Treatment of Human Cancer: A Balance between Efficacy and Toxicity

The diterpene ester ingenol-3-angelate (referred to as PEP005) is derived from the plant Euphorbia peplus. Crude euphorbia extract causes local toxicity and transient inflammation when applied topically and has been used in the treatment of warts, skin keratoses and skin cancer. PEP005 is a broad ra...

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Detalles Bibliográficos
Autores principales: Ersvaer, Elisabeth, Kittang, Astrid Olsnes, Hampson, Peter, Sand, Kristoffer, Gjertsen, Bjørn Tore, Lord, Janet M., Bruserud, Øystein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206618/
https://www.ncbi.nlm.nih.gov/pubmed/22069553
http://dx.doi.org/10.3390/toxins2010174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206618/
https://www.ncbi.nlm.nih.gov/pubmed/22069553
http://dx.doi.org/10.3390/toxins2010174

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