Cargando…

The Protein Kinase C Agonist PEP005 (Ingenol 3-Angelate) in the Treatment of Human Cancer: A Balance between Efficacy and Toxicity

The diterpene ester ingenol-3-angelate (referred to as PEP005) is derived from the plant Euphorbia peplus. Crude euphorbia extract causes local toxicity and transient inflammation when applied topically and has been used in the treatment of warts, skin keratoses and skin cancer. PEP005 is a broad ra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ersvaer, Elisabeth, Kittang, Astrid Olsnes, Hampson, Peter, Sand, Kristoffer, Gjertsen, Bjørn Tore, Lord, Janet M., Bruserud, Øystein
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International 2010
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206618/ https://www.ncbi.nlm.nih.gov/pubmed/22069553 http://dx.doi.org/10.3390/toxins2010174

Ejemplares similares

Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells
por: Hampson, Peter, et al.
Publicado: (2014)

The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia
por: Fredly, Hanne, et al.
Publicado: (2013)

Expression patterns of chemokine receptors on circulating T cells from myelodysplastic syndrome patients
por: Sand, Kristoffer Evebø, et al.
Publicado: (2013)

The Systemic Profile of Soluble Immune Mediators in Patients with Myelodysplastic Syndromes
por: Kittang, Astrid Olsnes, et al.
Publicado: (2016)

Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells
por: Benhadji, K A, et al.
Publicado: (2008)

Intensive chemotherapy for acute myeloid leukemia differentially affects circulating T(C)1, T(H)1, T(H)17 and T(REG )cells
por: Ersvaer, Elisabeth, et al.
Publicado: (2010)

The Possible Diagnostic and Prognostic Use of Systemic Chemokine Profiles in Clinical Medicine—The Experience in Acute Myeloid Leukemia from Disease Development and Diagnosis via Conventional Chemotherapy to Allogeneic Stem Cell Transplantation
por: Reikvam, Håkon, et al.
Publicado: (2013)

Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation
por: Jiang, Guochun, et al.
Publicado: (2015)

Acute Myeloid Leukemia with the t(8;21) Translocation: Clinical Consequences and Biological Implications
por: Reikvam, Håkon, et al.
Publicado: (2011)

Novel Antileukemic Compound Ingenol 3-Angelate Inhibits T Cell Apoptosis by Activating Protein Kinase Cθ
por: Lee, Wing-yiu, et al.
Publicado: (2010)

Targeting Cutaneous T-Cell Lymphoma Cells by Ingenol Mebutate (PEP005) Correlates with PKCδ Activation, ROS Induction as Well as Downregulation of XIAP and c-FLIP
por: Sumarni, Uly, et al.
Publicado: (2021)

Treatment of superficial basal cell carcinoma with ingenol mebutate gel, 0.05%
por: Bettencourt, Miriam S
Publicado: (2016)

Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents
por: Fredly, Hanne, et al.
Publicado: (2013)

Expansion of myeloid derived suppressor cells correlates with number of T regulatory cells and disease progression in myelodysplastic syndrome
por: Kittang, Astrid Olsnes, et al.
Publicado: (2015)

RasGRPs Are Targets of the Anti-Cancer Agent Ingenol-3-Angelate
por: Song, Xiaohua, et al.
Publicado: (2013)

Efficacy and safety of 0.05% ingenol mebutate in the treatment of basal cell carcinoma: A prospective study
por: Velin, Marine, et al.
Publicado: (2022)

Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine
por: Bredholt, Therese, et al.
Publicado: (2013)

Pre-apoptotic response to therapeutic DNA damage involves protein modulation of Mcl-1, Hdm2 and Flt3 in acute myeloid leukemia cells
por: Wergeland, Line, et al.
Publicado: (2007)

Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy
por: Grønningsæter, Ida Sofie, et al.
Publicado: (2019)

Combination of Intensive Chemotherapy and Anticancer Vaccines in the Treatment of Human Malignancies: The Hematological Experience
por: Liseth, Knut, et al.
Publicado: (2010)

Correlation analysis of two-dimensional gel electrophoretic protein patterns and biological variables
por: Van Belle, Werner, et al.
Publicado: (2006)

Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF-κB inhibition in acute myeloid leukemia (AML)
por: Omsland, Maria, et al.
Publicado: (2016)

Cascade targeting codelivery of ingenol-3-angelate and doxorubicin for enhancing cancer chemoimmunotherapy through synergistic effects in prostate cancer
por: Wang, Zhicheng, et al.
Publicado: (2021)

Disease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia – identification of responders by gene expression profiling of pretreatment leukemic cells
por: Reikvam, Håkon, et al.
Publicado: (2017)

Future Perspectives: Therapeutic Targeting of Notch Signalling May Become a Strategy in Patients Receiving Stem Cell Transplantation for Hematologic Malignancies
por: Ersvaer, Elisabeth, et al.
Publicado: (2011)

Myeloid-Derived Suppressor Cells in Hematologic Diseases: Promising Biomarkers and Treatment Targets
por: Bizymi, Nikoleta, et al.
Publicado: (2019)

Chronic Myeloid Leukemia Relapsing 25 Years after Allogenic Stem Cell Transplantation
por: Reikvam, Håkon, et al.
Publicado: (2018)

Ingenol mebutate treatment in keloids
por: De Felice, Bruna, et al.
Publicado: (2015)

Tattoo removal with ingenol mebutate
por: Cozzi, Sarah-Jane, et al.
Publicado: (2017)

Effects of cytarabine on activation of human T cells – cytarabine has concentration-dependent effects that are modulated both by valproic acid and all-trans retinoic acid
por: Ersvaer, Elisabeth, et al.
Publicado: (2015)

Interleukin-6 in Allogeneic Stem Cell Transplantation: Its Possible Importance for Immunoregulation and As a Therapeutic Target
por: Tvedt, Tor Henrik Anderson, et al.
Publicado: (2017)

Ingenol-3-Angelate Suppresses Growth of Melanoma Cells and Skin Tumor Development by Downregulation of NF-κB-Cox2 Signaling
por: Wang, Dunwei, et al.
Publicado: (2018)

Thrombosis and thrombocytopenia after HPV vaccination
por: Johansen, Silje, et al.
Publicado: (2022)

p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy
por: Haaland, Ingvild, et al.
Publicado: (2021)

Circulating monocyte subsets in multiple myeloma patients receiving autologous stem cell transplantation – a study of the preconditioning status and the course until posttransplant reconstitution for a consecutive group of patients
por: Rundgren, Ida Marie, et al.
Publicado: (2019)

A Pilot Study of Circulating Monocyte Subsets in Patients Treated with Stem Cell Transplantation for High-Risk Hematological Malignancies
por: Rundgren, Ida Marie, et al.
Publicado: (2020)

Genes of cell-cell interactions, chemotherapy detoxification and apoptosis are induced during chemotherapy of acute myeloid leukemia
por: Øyan, Anne Margrete, et al.
Publicado: (2009)

Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia
por: Forthun, Rakel Brendsdal, et al.
Publicado: (2019)

Peripheral Blood Stem Cell Mobilization in Healthy Donors by Granulocyte Colony-Stimulating Factor Causes Preferential Mobilization of Lymphocyte Subsets
por: Melve, Guro Kristin, et al.
Publicado: (2018)

Immunomodulatory Drugs Alter the Metabolism and the Extracellular Release of Soluble Mediators by Normal Monocytes
por: Rundgren, Ida Marie, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_38kd564mdstbs2da96vemsdf39