Cytotoxic Necrotizing Factors (CNFs)−A Growing Toxin Family

The Escherichia coli Cytotoxic Necrotizing Factors, CNF1, CNF2, CNF3 and CNFY from Yersinia pseudotuberculosis belong to a family of deamidating toxins. CNFs deamidate glutamine 63/61 in the switch II region of Rho GTPases that is essential for GTP hydrolysing activity. Deamidation leads to constitu...

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Detalles Bibliográficos
Autores principales: Knust, Zeynep, Schmidt, Gudula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206620/
https://www.ncbi.nlm.nih.gov/pubmed/22069550
http://dx.doi.org/10.3390/toxins2010116
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author Knust, Zeynep
Schmidt, Gudula
author_facet Knust, Zeynep
Schmidt, Gudula
author_sort Knust, Zeynep
collection PubMed
description The Escherichia coli Cytotoxic Necrotizing Factors, CNF1, CNF2, CNF3 and CNFY from Yersinia pseudotuberculosis belong to a family of deamidating toxins. CNFs deamidate glutamine 63/61 in the switch II region of Rho GTPases that is essential for GTP hydrolysing activity. Deamidation leads to constitutive activation of Rho GTPases. However, cellular mechanisms like proteasomal degradation of the activated Rho proteins restrict the action of the GTPases. This review describes the differences between the toxin family members concerning expression, cellular entry and substrate specificity.
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spelling pubmed-32066202011-11-08 Cytotoxic Necrotizing Factors (CNFs)−A Growing Toxin Family Knust, Zeynep Schmidt, Gudula Toxins (Basel) Review The Escherichia coli Cytotoxic Necrotizing Factors, CNF1, CNF2, CNF3 and CNFY from Yersinia pseudotuberculosis belong to a family of deamidating toxins. CNFs deamidate glutamine 63/61 in the switch II region of Rho GTPases that is essential for GTP hydrolysing activity. Deamidation leads to constitutive activation of Rho GTPases. However, cellular mechanisms like proteasomal degradation of the activated Rho proteins restrict the action of the GTPases. This review describes the differences between the toxin family members concerning expression, cellular entry and substrate specificity. Molecular Diversity Preservation International 2011-04-08 /pmc/articles/PMC3206620/ /pubmed/22069550 http://dx.doi.org/10.3390/toxins2010116 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Knust, Zeynep
Schmidt, Gudula
Cytotoxic Necrotizing Factors (CNFs)−A Growing Toxin Family
title Cytotoxic Necrotizing Factors (CNFs)−A Growing Toxin Family
title_full Cytotoxic Necrotizing Factors (CNFs)−A Growing Toxin Family
title_fullStr Cytotoxic Necrotizing Factors (CNFs)−A Growing Toxin Family
title_full_unstemmed Cytotoxic Necrotizing Factors (CNFs)−A Growing Toxin Family
title_short Cytotoxic Necrotizing Factors (CNFs)−A Growing Toxin Family
title_sort cytotoxic necrotizing factors (cnfs)−a growing toxin family
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206620/
https://www.ncbi.nlm.nih.gov/pubmed/22069550
http://dx.doi.org/10.3390/toxins2010116
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