PDZ binding of TARP©-8 controls synaptic transmission, but not synaptic plasticity

Reduction in synaptic transmission and plasticity in mice lacking the hippocampus-enriched AMPAR auxiliary subunit, TARP©-8, could be due to reduction in AMPAR expression or a direct role of ©-8. Here, we generated TARP©-8Δ4 knock-in mice lacking the C-terminal PDZ ligand. We found that synaptic tra...

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Detalles Bibliográficos
Autores principales: Sumioka, Akio, Brown, Travis, Kato, Akihiko, Bredt, David S., Kauer, Julie A., Tomita, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206644/
https://www.ncbi.nlm.nih.gov/pubmed/22002768
http://dx.doi.org/10.1038/nn.2952
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author Sumioka, Akio
Brown, Travis
Kato, Akihiko
Bredt, David S.
Kauer, Julie A.
Tomita, Susumu
author_facet Sumioka, Akio
Brown, Travis
Kato, Akihiko
Bredt, David S.
Kauer, Julie A.
Tomita, Susumu
author_sort Sumioka, Akio
collection PubMed
description Reduction in synaptic transmission and plasticity in mice lacking the hippocampus-enriched AMPAR auxiliary subunit, TARP©-8, could be due to reduction in AMPAR expression or a direct role of ©-8. Here, we generated TARP©-8Δ4 knock-in mice lacking the C-terminal PDZ ligand. We found that synaptic transmission and AMPAR were reduced without changes in extrasynaptic AMPAR expression, but LTP was unaltered. Our findings indicate distinct TARP-dependent mechanisms for synaptic transmission and LTP.
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spelling pubmed-32066442012-05-01 PDZ binding of TARP©-8 controls synaptic transmission, but not synaptic plasticity Sumioka, Akio Brown, Travis Kato, Akihiko Bredt, David S. Kauer, Julie A. Tomita, Susumu Nat Neurosci Article Reduction in synaptic transmission and plasticity in mice lacking the hippocampus-enriched AMPAR auxiliary subunit, TARP©-8, could be due to reduction in AMPAR expression or a direct role of ©-8. Here, we generated TARP©-8Δ4 knock-in mice lacking the C-terminal PDZ ligand. We found that synaptic transmission and AMPAR were reduced without changes in extrasynaptic AMPAR expression, but LTP was unaltered. Our findings indicate distinct TARP-dependent mechanisms for synaptic transmission and LTP. 2011-10-16 /pmc/articles/PMC3206644/ /pubmed/22002768 http://dx.doi.org/10.1038/nn.2952 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Sumioka, Akio
Brown, Travis
Kato, Akihiko
Bredt, David S.
Kauer, Julie A.
Tomita, Susumu
PDZ binding of TARP©-8 controls synaptic transmission, but not synaptic plasticity
title PDZ binding of TARP©-8 controls synaptic transmission, but not synaptic plasticity
title_full PDZ binding of TARP©-8 controls synaptic transmission, but not synaptic plasticity
title_fullStr PDZ binding of TARP©-8 controls synaptic transmission, but not synaptic plasticity
title_full_unstemmed PDZ binding of TARP©-8 controls synaptic transmission, but not synaptic plasticity
title_short PDZ binding of TARP©-8 controls synaptic transmission, but not synaptic plasticity
title_sort pdz binding of tarp©-8 controls synaptic transmission, but not synaptic plasticity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206644/
https://www.ncbi.nlm.nih.gov/pubmed/22002768
http://dx.doi.org/10.1038/nn.2952
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