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Progranulin and TDP-43: Mechanistic Links and Future Directions
Loss-of-function mutations in the multifunctional growth factor progranulin (GRN) cause frontotemporal lobar degeneration (FTLD) with TDP-43 protein accumulation. Nuclear TDP-43 protein with key roles in RNA metabolism is also aggregated in amyotrophic lateral sclerosis (ALS), suggesting that ALS an...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Humana Press Inc
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207122/ https://www.ncbi.nlm.nih.gov/pubmed/21863317 http://dx.doi.org/10.1007/s12031-011-9625-0 |