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Progranulin and TDP-43: Mechanistic Links and Future Directions

Loss-of-function mutations in the multifunctional growth factor progranulin (GRN) cause frontotemporal lobar degeneration (FTLD) with TDP-43 protein accumulation. Nuclear TDP-43 protein with key roles in RNA metabolism is also aggregated in amyotrophic lateral sclerosis (ALS), suggesting that ALS an...

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Detalles Bibliográficos
Autor principal:	Kumar-Singh, Samir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Humana Press Inc 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207122/ https://www.ncbi.nlm.nih.gov/pubmed/21863317 http://dx.doi.org/10.1007/s12031-011-9625-0

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