Model Organisms Reveal Insight into Human Neurodegenerative Disease: Ataxin-2 Intermediate-Length Polyglutamine Expansions Are a Risk Factor for ALS

Model organisms include yeast Saccromyces cerevisae and fly Drosophila melanogaster. These systems have powerful genetic approaches, as well as highly conserved pathways, both for normal function and disease. Here, we review and highlight how we applied these systems to provide mechanistic insight i...

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Detalles Bibliográficos
Autores principales: Bonini, Nancy M., Gitler, Aaron D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Humana Press Inc 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207127/
https://www.ncbi.nlm.nih.gov/pubmed/21660502
http://dx.doi.org/10.1007/s12031-011-9548-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207127/
https://www.ncbi.nlm.nih.gov/pubmed/21660502
http://dx.doi.org/10.1007/s12031-011-9548-9

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