Claudin-1 induced sealing of blood–brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis

In experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis (MS), loss of the blood–brain barrier (BBB) tight junction (TJ) protein claudin-3 correlates with immune cell infiltration into the CNS and BBB leakiness. Here we show that sealing BBB TJs by ectopic tetracycl...

Descripción completa

Detalles Bibliográficos
Autores principales: Pfeiffer, Friederike, Schäfer, Julia, Lyck, Ruth, Makrides, Victoria, Brunner, Sarah, Schaeren-Wiemers, Nicole, Deutsch, Urban, Engelhardt, Britta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207130/
https://www.ncbi.nlm.nih.gov/pubmed/21983942
http://dx.doi.org/10.1007/s00401-011-0883-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207130/
https://www.ncbi.nlm.nih.gov/pubmed/21983942
http://dx.doi.org/10.1007/s00401-011-0883-2

Ejemplares similares