Phase I Evaluation of STA-1474, a Prodrug of the Novel HSP90 Inhibitor Ganetespib, in Dogs with Spontaneous Cancer

BACKGROUND: The novel water soluble compound STA-1474 is metabolized to ganetespib (formerly STA-9090), a potent HSP90 inhibitor previously shown to kill canine tumor cell lines in vitro and inhibit tumor growth in the setting of murine xenografts. The purpose of the following study was to extend th...

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Detalles Bibliográficos
Autores principales: London, Cheryl A., Bear, Misty D., McCleese, Jennifer, Foley, Kevin P., Paalangara, Reji, Inoue, Takayo, Ying, Weiwen, Barsoum, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207826/
https://www.ncbi.nlm.nih.gov/pubmed/22073242
http://dx.doi.org/10.1371/journal.pone.0027018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207826/
https://www.ncbi.nlm.nih.gov/pubmed/22073242
http://dx.doi.org/10.1371/journal.pone.0027018

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