Characterization of a Novel Type of HIV-1 Particle Assembly Inhibitor Using a Quantitative Luciferase-Vpr Packaging-Based Assay

The HIV-1 auxiliary protein Vpr and Vpr-fusion proteins can be copackaged with Gag precursor (Pr55Gag) into virions or membrane-enveloped virus-like particles (VLP). Taking advantage of this property, we developed a simple and sensitive method to evaluate potential inhibitors of HIV-1 assembly in a...

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Detalles Bibliográficos
Autores principales: Gonzalez, Gaëlle, DaFonseca, Sandrina, Errazuriz, Elisabeth, Coric, Pascale, Souquet, Florence, Turcaud, Serge, Boulanger, Pierre, Bouaziz, Serge, Hong, Saw See
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207847/
https://www.ncbi.nlm.nih.gov/pubmed/22073298
http://dx.doi.org/10.1371/journal.pone.0027234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207847/
https://www.ncbi.nlm.nih.gov/pubmed/22073298
http://dx.doi.org/10.1371/journal.pone.0027234

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