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Characterization of a Novel Type of HIV-1 Particle Assembly Inhibitor Using a Quantitative Luciferase-Vpr Packaging-Based Assay
The HIV-1 auxiliary protein Vpr and Vpr-fusion proteins can be copackaged with Gag precursor (Pr55Gag) into virions or membrane-enveloped virus-like particles (VLP). Taking advantage of this property, we developed a simple and sensitive method to evaluate potential inhibitors of HIV-1 assembly in a...
Autores principales: | Gonzalez, Gaëlle, DaFonseca, Sandrina, Errazuriz, Elisabeth, Coric, Pascale, Souquet, Florence, Turcaud, Serge, Boulanger, Pierre, Bouaziz, Serge, Hong, Saw See |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207847/ https://www.ncbi.nlm.nih.gov/pubmed/22073298 http://dx.doi.org/10.1371/journal.pone.0027234 |
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