PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma

The PI3K-Akt pathway is activated in cancer by genetic or epigenetic events and efforts are under way to develop targeted therapies. PTEN tumor suppressor is the major brake of the pathway and a common target for inactivation in glioblastoma, one of the most aggressive and therapy-resistant cancers....

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Detalles Bibliográficos
Autores principales: Molina, Jennifer R., Agarwal, Nitin K., Morales, Fabiana C., Hayashi, Yuho, Aldape, Kenneth D., Cote, Gilbert, Georgescu, Maria-Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208076/
https://www.ncbi.nlm.nih.gov/pubmed/21804599
http://dx.doi.org/10.1038/onc.2011.324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208076/
https://www.ncbi.nlm.nih.gov/pubmed/21804599
http://dx.doi.org/10.1038/onc.2011.324

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