Redox-Based Inactivation of Cysteine Cathepsins by Compounds Containing the 4-Aminophenol Moiety

BACKGROUND: Redox cycling compounds have been reported to cause false positive inhibition of proteases in drug discovery studies. This kind of false positives can lead to unusually high hit rates in high-throughput screening campaigns and require further analysis to distinguish true from false posit...

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Detalles Bibliográficos
Autores principales: Mirković, Bojana, Sosič, Izidor, Gobec, Stanislav, Kos, Janko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208577/
https://www.ncbi.nlm.nih.gov/pubmed/22073285
http://dx.doi.org/10.1371/journal.pone.0027197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208577/
https://www.ncbi.nlm.nih.gov/pubmed/22073285
http://dx.doi.org/10.1371/journal.pone.0027197

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