Intravenous Neuromyelitis Optica Autoantibody in Mice Targets Aquaporin-4 in Peripheral Organs and Area Postrema

The pathogenesis of neuromyelitis optica (NMO) involves binding of IgG autoantibodies (NMO-IgG) to aquaporin-4 (AQP4) on astrocytes in the central nervous system (CNS). We studied the in vivo processing in mice of a recombinant monoclonal human NMO-IgG that binds strongly to mouse AQP4. Following in...

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Detalles Bibliográficos
Autores principales: Ratelade, Julien, Bennett, Jeffrey L., Verkman, A. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208637/
https://www.ncbi.nlm.nih.gov/pubmed/22076159
http://dx.doi.org/10.1371/journal.pone.0027412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208637/
https://www.ncbi.nlm.nih.gov/pubmed/22076159
http://dx.doi.org/10.1371/journal.pone.0027412

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