Development and validation of a yeast high-throughput screen for inhibitors of Aβ(42) oligomerization

Recent reports point to small soluble oligomers, rather than insoluble fibrils, of amyloid β (Aβ), as the primary toxic species in Alzheimer’s disease. Previously, we developed a low-throughput assay in yeast that is capable of detecting small Aβ(42) oligomer formation. Specifically, Aβ(42) fused to...

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Detalles Bibliográficos
Autores principales: Park, Sei-Kyoung, Pegan, Scott D., Mesecar, Andrew D., Jungbauer, Lisa M., LaDu, Mary Jo, Liebman, Susan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209651/
https://www.ncbi.nlm.nih.gov/pubmed/21810907
http://dx.doi.org/10.1242/dmm.007963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209651/
https://www.ncbi.nlm.nih.gov/pubmed/21810907
http://dx.doi.org/10.1242/dmm.007963

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