Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas

In tumours, aberrant splicing generates variants that contribute to multiple aspects of tumour establishment, progression and maintenance. We show that in glioblastoma multiforme (GBM) specimens, death-domain adaptor protein Insuloma-Glucagonoma protein 20 (IG20) is consistently aberrantly spliced t...

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Detalles Bibliográficos
Autores principales: LeFave, Clare V, Squatrito, Massimo, Vorlova, Sandra, Rocco, Gina L, Brennan, Cameron W, Holland, Eric C, Pan, Ying-Xian, Cartegni, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209773/
https://www.ncbi.nlm.nih.gov/pubmed/21915099
http://dx.doi.org/10.1038/emboj.2011.259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209773/
https://www.ncbi.nlm.nih.gov/pubmed/21915099
http://dx.doi.org/10.1038/emboj.2011.259

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