G12 Signaling through c-Jun NH(2)-Terminal Kinase Promotes Breast Cancer Cell Invasion

Signaling through the heterotrimeric G protein, G12, via Rho induces a striking increase in breast cancer cell invasion. In this study, evidence is provided that the c-Jun NH(2)-terminal kinase (JNK) is a key downstream effector of G12 on this pathway. Expression of constitutively-active Gα12 or act...

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Detalles Bibliográficos
Autores principales: Juneja, Juhi, Cushman, Ian, Casey, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210117/
https://www.ncbi.nlm.nih.gov/pubmed/22087220
http://dx.doi.org/10.1371/journal.pone.0026085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210117/
https://www.ncbi.nlm.nih.gov/pubmed/22087220
http://dx.doi.org/10.1371/journal.pone.0026085

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