ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand-binding

The extent to which ligand occupancy and dimerization contribute to erbB1 signaling is controversial. To examine this, we utilized two-color Quantum Dot tracking for visualization of erbB1 homodimerization and quantification of the dimer off rate (k(off)) on living cells. Kinetic parameters were ext...

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Detalles Bibliográficos
Autores principales: Low-Nam, Shalini T., Lidke, Keith A., Cutler, Patrick J., Roovers, Rob C., van Bergen en Henegouwen, Paul M.P., Wilson, Bridget S., Lidke, Diane S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210321/
https://www.ncbi.nlm.nih.gov/pubmed/22020299
http://dx.doi.org/10.1038/nsmb.2135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210321/
https://www.ncbi.nlm.nih.gov/pubmed/22020299
http://dx.doi.org/10.1038/nsmb.2135

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