Peptides from aminoacyl-tRNA synthetases can cure the defects due to mutations in mt tRNA genes

Recent results from several laboratories have confirmed that human and yeast leucyl- and valyl-tRNA synthetases can rescue the respiratory defects due to mutations in mitochondrial tRNA genes. In this report we show that this effect cannot be ascribed to the catalytic activity per se and that isolat...

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Detalles Bibliográficos
Autores principales: Francisci, Silvia, Montanari, Arianna, De Luca, Cristina, Frontali, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210327/
https://www.ncbi.nlm.nih.gov/pubmed/21903180
http://dx.doi.org/10.1016/j.mito.2011.08.006
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author Francisci, Silvia
Montanari, Arianna
De Luca, Cristina
Frontali, Laura
author_facet Francisci, Silvia
Montanari, Arianna
De Luca, Cristina
Frontali, Laura
author_sort Francisci, Silvia
collection PubMed
description Recent results from several laboratories have confirmed that human and yeast leucyl- and valyl-tRNA synthetases can rescue the respiratory defects due to mutations in mitochondrial tRNA genes. In this report we show that this effect cannot be ascribed to the catalytic activity per se and that isolated domains of aminoacyl-tRNA synthetases and even short peptides thereof have suppressing effects.
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spelling pubmed-32103272011-12-28 Peptides from aminoacyl-tRNA synthetases can cure the defects due to mutations in mt tRNA genes Francisci, Silvia Montanari, Arianna De Luca, Cristina Frontali, Laura Mitochondrion Article Recent results from several laboratories have confirmed that human and yeast leucyl- and valyl-tRNA synthetases can rescue the respiratory defects due to mutations in mitochondrial tRNA genes. In this report we show that this effect cannot be ascribed to the catalytic activity per se and that isolated domains of aminoacyl-tRNA synthetases and even short peptides thereof have suppressing effects. Elsevier Science 2011-11 /pmc/articles/PMC3210327/ /pubmed/21903180 http://dx.doi.org/10.1016/j.mito.2011.08.006 Text en © 2011 Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/3.0/ Open Access under CC BY-NC-ND 3.0 (https://creativecommons.org/licenses/by-nc-nd/3.0/) license
spellingShingle Article
Francisci, Silvia
Montanari, Arianna
De Luca, Cristina
Frontali, Laura
Peptides from aminoacyl-tRNA synthetases can cure the defects due to mutations in mt tRNA genes
title Peptides from aminoacyl-tRNA synthetases can cure the defects due to mutations in mt tRNA genes
title_full Peptides from aminoacyl-tRNA synthetases can cure the defects due to mutations in mt tRNA genes
title_fullStr Peptides from aminoacyl-tRNA synthetases can cure the defects due to mutations in mt tRNA genes
title_full_unstemmed Peptides from aminoacyl-tRNA synthetases can cure the defects due to mutations in mt tRNA genes
title_short Peptides from aminoacyl-tRNA synthetases can cure the defects due to mutations in mt tRNA genes
title_sort peptides from aminoacyl-trna synthetases can cure the defects due to mutations in mt trna genes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210327/
https://www.ncbi.nlm.nih.gov/pubmed/21903180
http://dx.doi.org/10.1016/j.mito.2011.08.006
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