In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions

The maintenance of H3K9 and DNA methylation at imprinting control regions (ICRs) during early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57, its cofactor KAP1, and associated effectors bind selectively to the H3K9me3-bearing, DNA-methylated allele of ICRs in E...

Descripción completa

Detalles Bibliográficos
Autores principales: Quenneville, Simon, Verde, Gaetano, Corsinotti, Andrea, Kapopoulou, Adamandia, Jakobsson, Johan, Offner, Sandra, Baglivo, Ilaria, Pedone, Paolo V., Grimaldi, Giovanna, Riccio, Andrea, Trono, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210328/
https://www.ncbi.nlm.nih.gov/pubmed/22055183
http://dx.doi.org/10.1016/j.molcel.2011.08.032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210328/
https://www.ncbi.nlm.nih.gov/pubmed/22055183
http://dx.doi.org/10.1016/j.molcel.2011.08.032

Ejemplares similares