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In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions
The maintenance of H3K9 and DNA methylation at imprinting control regions (ICRs) during early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57, its cofactor KAP1, and associated effectors bind selectively to the H3K9me3-bearing, DNA-methylated allele of ICRs in E...
Autores principales: | Quenneville, Simon, Verde, Gaetano, Corsinotti, Andrea, Kapopoulou, Adamandia, Jakobsson, Johan, Offner, Sandra, Baglivo, Ilaria, Pedone, Paolo V., Grimaldi, Giovanna, Riccio, Andrea, Trono, Didier |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210328/ https://www.ncbi.nlm.nih.gov/pubmed/22055183 http://dx.doi.org/10.1016/j.molcel.2011.08.032 |
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