An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes

AIMS/HYPOTHESIS: Intronic single nucleotide polymorphisms within the transcription factor 7-like 2 (TCF7L2) gene are associated with risk of type 2 diabetes. It is widely hypothesised that the predisposing variation is involved in cis-regulation of TCF7L2 activity. The aim of this study was to seek...

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Detalles Bibliográficos
Autores principales: Locke, J. M., Da Silva Xavier, G., Rutter, G. A., Harries, L. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210366/
https://www.ncbi.nlm.nih.gov/pubmed/21913056
http://dx.doi.org/10.1007/s00125-011-2290-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210366/
https://www.ncbi.nlm.nih.gov/pubmed/21913056
http://dx.doi.org/10.1007/s00125-011-2290-6

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