Structure of an Aprataxin–DNA complex with insights into AOA1 Neurodegenerative Disease

DNA ligases finalize DNA replication and repair through DNA nick-sealing reactions that can abort to generate cytotoxic 5′-adenylation DNA damage (5′-AMP). Aprataxin (Aptx) catalyses direct reversal of 5′-AMP adducts to protect genome integrity. Here, the structure of an Aptx-DNA-AMP-Zn complex reve...

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Detalles Bibliográficos
Autores principales: Tumbale, Percy, Appel, C. Denise, Kraehenbuehl, Rolf, Robertson, Patrick D., Williams, Jessica S., Krahn, Joe, Ahel, Ivan, Williams, R. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210380/
https://www.ncbi.nlm.nih.gov/pubmed/21984210
http://dx.doi.org/10.1038/nsmb.2146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210380/
https://www.ncbi.nlm.nih.gov/pubmed/21984210
http://dx.doi.org/10.1038/nsmb.2146

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