Cargando…

Structure of an Aprataxin–DNA complex with insights into AOA1 Neurodegenerative Disease

DNA ligases finalize DNA replication and repair through DNA nick-sealing reactions that can abort to generate cytotoxic 5′-adenylation DNA damage (5′-AMP). Aprataxin (Aptx) catalyses direct reversal of 5′-AMP adducts to protect genome integrity. Here, the structure of an Aptx-DNA-AMP-Zn complex reve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tumbale, Percy, Appel, C. Denise, Kraehenbuehl, Rolf, Robertson, Patrick D., Williams, Jessica S., Krahn, Joe, Ahel, Ivan, Williams, R. Scott
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210380/ https://www.ncbi.nlm.nih.gov/pubmed/21984210 http://dx.doi.org/10.1038/nsmb.2146

Ejemplares similares

Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity
por: Tumbale, Percy, et al.
Publicado: (2013)

Progressive ataxia associated with ocular apraxia type 1 (AOA1) with a presence of a novel mutation on the aprataxin gene
por: Rana, Abdul Qayyum, et al.
Publicado: (2013)

Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3′-phosphate and 3′-phosphoglycolate ends
por: Takahashi, Tetsuya, et al.
Publicado: (2007)

Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease
por: Tumbale, Percy, et al.
Publicado: (2018)

Complementation of aprataxin deficiency by base excision repair enzymes
por: Çağlayan, Melike, et al.
Publicado: (2015)

Pseudodominant AOA2
por: Newrick, Laurence, et al.
Publicado: (2015)

Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts
por: Çağlayan, Melike, et al.
Publicado: (2017)

miR-424 acts as a tumor radiosensitizer by targeting aprataxin in cervical cancer
por: Wang, Xia, et al.
Publicado: (2016)

High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication
por: Williams, Jessica S., et al.
Publicado: (2021)

CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response
por: Becherel, Olivier J., et al.
Publicado: (2010)

Optimal Geometries for AOA Localization in the Bayesian Sense
por: Dogancay, Kutluyil
Publicado: (2022)

Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis
por: Kaminski, Andrea M., et al.
Publicado: (2018)

Comparing ataxias with oculomotor apraxia: a multimodal study of AOA1, AOA2 and AT focusing on video-oculography and alpha-fetoprotein
por: Mariani, L. L., et al.
Publicado: (2017)

Transformative Leadership: Emergency Physicians Lead AOA and AMA
por: Kraus, Chadd K.
Publicado: (2015)

Closed-Form Pseudolinear Estimators for DRSS-AOA Localization
por: Li, Jun, et al.
Publicado: (2021)

On Target Localization Using Combined RSS and AoA Measurements
por: Tomic, Slavisa, et al.
Publicado: (2018)

A Case of AOA2 With Compound Heterozygous SETX Mutations
por: Chang, Hee Jin, et al.
Publicado: (2022)

Two-tiered enforcement of high-fidelity DNA ligation
por: Tumbale, Percy P., et al.
Publicado: (2019)

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage
por: Richard, Patricia, et al.
Publicado: (2013)

Molecular basis for processing of topoisomerase 1-triggered DNA damage by Apn2/APE2
por: Williams, Jessica S., et al.
Publicado: (2022)

Unbalanced Hybrid AOA/RSSI Localization for Simplified Wireless Sensor Networks
por: Le, Anh Tuyen, et al.
Publicado: (2020)

Three-Dimensional Empirical AoA Localization Technique for Indoor Applications
por: Alma’aitah, Abdallah, et al.
Publicado: (2019)

Cascade AOA Estimation Algorithm Based on Flexible Massive Antenna Array
por: Kim, Tae-yun, et al.
Publicado: (2020)

An SOCP Estimator for Hybrid RSS and AOA Target Localization in Sensor Networks
por: Costa, Marcelo Salgueiro, et al.
Publicado: (2021)

Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin
por: El-Khamisy, Sherif F., et al.
Publicado: (2009)

Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains
por: Cherry, Amy L., et al.
Publicado: (2015)

DNA(3′)pp(5′)G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition
por: Chauleau, Mathieu, et al.
Publicado: (2015)

Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing
por: Carroll, Jean, et al.
Publicado: (2015)

Adaptive AOA-Aided TOA Self-Positioning for Mobile Wireless Sensor Networks
por: Wen, Chih-Yu, et al.
Publicado: (2010)

Decentralized Cooperative TOA/AOA Target Tracking for Hierarchical Wireless Sensor Networks
por: Chen, Ying-Chih, et al.
Publicado: (2012)

The impact of temperature on microbial diversity and AOA activity in the Tengchong Geothermal Field, China
por: Li, Haizhou, et al.
Publicado: (2015)

Using the Fingerprinting Method to Customize RTLS Based on the AoA Ranging Technique
por: Jachimczyk, Bartosz, et al.
Publicado: (2016)

Target Tracking with Sensor Navigation Using Coupled RSS and AoA Measurements
por: Tomic, Slavisa, et al.
Publicado: (2017)

Influence of Glycine and Arginine on Cylindrospermopsin Production and aoa Gene Expression in Aphanizomenon ovalisporum
por: Barón-Sola, Ángel, et al.
Publicado: (2017)

Overview of the AOA National Joint Replacement Registry: ACL Registry Pilot Study
por: Clarnette, Richard, et al.
Publicado: (2016)

A Machine Learning Approach to Improve Ranging Accuracy with AoA and RSSI
por: Zhang, Tingwei, et al.
Publicado: (2022)

Photonics-Based Simultaneous DFS and AOA Measurement System without Direction Ambiguity
por: Meng, Qingqing, et al.
Publicado: (2023)

MRI findings in AOA2: Cerebellar atrophy and abnormal iron detection in dentate nucleus()
por: Frismand, Solène, et al.
Publicado: (2013)

AOA-Based Three-Dimensional Multi-Target Localization in Industrial WSNs for LOS Conditions
por: Zhang, Ruonan, et al.
Publicado: (2018)

An Efficient Hybrid RSS-AoA Localization for 3D Wireless Sensor Networks
por: L. N. Nguyen, Thu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ftg3skbtdb03bdui5lu54ghcrn