Studies on Synthesis and Structure-Activity Relationship (SAR) of Derivatives of a New Natural Product from Marine Fungi as Inhibitors of Influenza Virus Neuraminidase

Based on the natural isoprenyl phenyl ether from a mangrove-derived fungus, 32 analogues were synthesized and evaluated for inhibitory activity against influenza H1N1 neuraminidase. Compound 15 (3-(allyloxy)-4-hydroxybenzaldehyde) exhibited the most potent inhibitory activity, with IC(50) values of...

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Detalles Bibliográficos
Autores principales: Li, Jing, Zhang, Dingmei, Zhu, Xun, He, Zhenjian, Liu, Shu, Li, Mengfeng, Pang, Jiyan, Lin, Yongcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210610/
https://www.ncbi.nlm.nih.gov/pubmed/22073001
http://dx.doi.org/10.3390/md9101887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210610/
https://www.ncbi.nlm.nih.gov/pubmed/22073001
http://dx.doi.org/10.3390/md9101887

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